Anti-Complement factor 8 beta antibody (ab111700)

Overview

  • Product name
    Anti-Complement factor 8 beta antibody
    See all Complement factor 8 beta primary antibodies
  • Description
    Rabbit polyclonal to Complement factor 8 beta
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rabbit
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 412-563 of Human Complement factor 8 beta (AAI30576).

  • Positive control
    • HeLa, HepG2 and HCT116 whole cell lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1% BSA, 20% Glycerol, PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111700 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 67 kDa.

Target

  • Function
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
  • Involvement in disease
    Defects in C8B are a cause of complement component 8 deficiency type 2 (C8D2) [MIM:120960]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
  • Sequence similarities
    Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 TSP type-1 domains.
  • Post-translational
    modifications
    N-glycosylated; contains one or two bound glycans. Not O-glycosylated.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • C8b antibody
    • CO8B_HUMAN antibody
    • Complement component 8 beta polypeptide antibody
    • Complement component 8 subunit beta antibody
    • Complement component C8 beta chain antibody
    see all

Images

  • Anti-Complement factor 8 beta antibody (ab111700) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg

    Predicted band size : 67 kDa

References

ab111700 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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