Anti-Complement factor B antibody [M13/12] (ab106139)
Key features and details
- Mouse monoclonal [M13/12] to Complement factor B
- Suitable for: IP, WB
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-Complement factor B antibody [M13/12]
See all Complement factor B primary antibodies -
Description
Mouse monoclonal [M13/12] to Complement factor B -
Host species
Mouse -
Specificity
ab106139 recognizes complement factor B/Bb -
Tested applications
Suitable for: IP, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Full length protein corresponding to Complement factor B. Complement factor B/Bb
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituents: 0.1% BSA, PBS -
Concentration information loading...
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Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
M13/12 -
Isotype
IgG1
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106139 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IP |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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Notes |
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IP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Relevance
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes. -
Cellular localization
Plasma membrane and Secreted -
Database links
- Entrez Gene: 629 Human
- Omim: 138470 Human
- SwissProt: P00751 Human
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Alternative names
- C3/C5 convertase antibody
- Complement factor B antibody
- Glycine-rich beta glycoprotein antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (2)
ab106139 has been referenced in 2 publications.
- Oppermann M et al. Elevated plasma levels of the immunosuppressive complement fragment Ba in renal failure. Kidney Int 40:939-47 (1991). PubMed: 1837062
- Oppermann M et al. Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays. J Immunol Methods 133:181-90 (1990). PubMed: 2146321