Overview

  • Product name
    Anti-Complement factor B antibody [M13/12]
    See all Complement factor B primary antibodies
  • Description
    Mouse monoclonal [M13/12] to Complement factor B
  • Specificity
    ab106139 recognizes complement factor B/Bb
  • Tested applications
    Suitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Complement factor B/Bb

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Monoclonal
  • Clone number
    M13/12
  • Isotype
    IgG1

Applications

Our Abpromise guarantee covers the use of ab106139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/50. Predicted molecular weight: 86 kDa.
IP Use at an assay dependent dilution.

Target

  • Relevance
    Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
  • Cellular localization
    Plasma membrane and Secreted
  • Database links
  • Alternative names
    • C3/C5 convertase antibody
    • Complement factor B antibody
    • Glycine-rich beta glycoprotein antibody
    • PBF2 antibody
    • Properdin factor B antibody
    see all

References

This product has been referenced in:
  • Oppermann M  et al. Elevated plasma levels of the immunosuppressive complement fragment Ba in renal failure. Kidney Int 40:939-47 (1991). Read more (PubMed: 1837062) »
  • Oppermann M  et al. Quantitation of components of the alternative pathway of complement (APC) by enzyme-linked immunosorbent assays. J Immunol Methods 133:181-90 (1990). Read more (PubMed: 2146321) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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