Overview

  • Product name
  • Description
    Goat polyclonal to COMT
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Dog
  • Immunogen

    Synthetic peptide:

    GDTKEQRILNHVLQC

    , corresponding to N-terminal amino acids 52-60 of Human COMT.

  • Positive control
    • Human Kidney and Prostate tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab113521 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 30 kDa.
ELISA 1/4000.
IHC-P Use a concentration of 3.75 µg/ml.

Target

  • Function
    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
  • Tissue specificity
    Brain, liver, placenta, lymphocytes and erythrocytes.
  • Sequence similarities
    Belongs to the mammalian catechol-O-methyltransferase family.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localization
    Cytoplasm and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Catechol O methyltransferase antibody
    • Catechol O-methyltransferase antibody
    • COMT antibody
    • COMT_HUMAN antibody
    • EC 2.1.1.6 antibody
    see all

Images

  • ab113521, at 3.75µg/ml, staining COMT in Formalin-fixed, Paraffin-embedded Human kidney tissue by Immunohistochemistry.
  • ab113521, at 3.75µg/ml, staining COMT in Formalin-fixed, Paraffin-embedded Human prostate tissue by Immunohistochemistry.

References

ab113521 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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