Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      GDTKEQRILNHVLQ-C
    • Amino acids
      52 to 65

Associated products

Specifications

Our Abpromise guarantee covers the use of ab45665 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-COMT antibody (ab36144)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • Catechol O methyltransferase
    • Catechol O-methyltransferase
    • COMT
    • COMT_HUMAN
    • EC 2.1.1.6
    see all
  • Function
    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
  • Tissue specificity
    Brain, liver, placenta, lymphocytes and erythrocytes.
  • Sequence similarities
    Belongs to the mammalian catechol-O-methyltransferase family.
  • Post-translational
    modifications
    The N-terminus is blocked.
  • Cellular localization
    Cytoplasm and Cell membrane.
  • Information by UniProt

References

ab45665 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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