Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionContactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
Tissue specificityExpressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
Sequence similaritiesBelongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Western blot - Anti-Contactin 6 antibody (ab91384)
Anti-Contactin 6 antibody (ab91384) at 1/100 dilution + HL60 cell lysate at 35 µg
Predicted band size : 114 kDa
References for Anti-Contactin 6 antibody (ab91384)
This product has been referenced in:
Cheong YK et al. Identification of cell surface markers glypican-4 and CD200 that differentiate human corneal endothelium from stromal fibroblasts. Invest Ophthalmol Vis Sci54:4538-47 (2013).
Read more (PubMed: 23744997) »