Overview

  • Product nameAnti-COP antibody
    See all COP primary antibodies
  • Description
    Mouse monoclonal to COP
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: MADKVLKEKR KLFIHSMGEG TINGLLDELL QTRVLNQEEM EKVKRENATV MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAETLGLS AGPIPGN, corresponding to amino acids 1-98 of Human COP

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCaspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
    • Tissue specificityWidely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus.
    • Sequence similaritiesContains 1 CARD domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAR16_HUMAN antibody
      • CARD only domain-containing protein 1 antibody
      • CARD only protein antibody
      • CARD16 antibody
      • Caspase recruitment domain family, member 16 antibody
      • Caspase recruitment domain-containing protein 16 antibody
      • Caspase-1 dominant-negative inhibitor pseudo-ICE antibody
      • Caspase-1 inhibitor COP antibody
      • COP antibody
      • COP1 antibody
      • Pseudo interleukin 1 beta converting enzyme antibody
      • Pseudo interleukin-1 beta converting enzyme antibody
      • Pseudo interleukin-1beta converting enzyme antibody
      • PSEUDO-ICE antibody
      see all

    Anti-COP antibody images

    • Western blot against tagged recombinant protein immunogen using ab57714 COP antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-COP antibody (ab57714)

    ab57714 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57714.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"