Overview

  • Product nameAnti-COPE antibody
    See all COPE primary antibodies
  • Description
    Mouse polyclonal to COPE
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein corresponding to amino acids 1-308 of Human COPE (NP_009194.2).

  • Positive control
    • Human liver lysate, COPE transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab88824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 34 kDa.

Target

  • FunctionThe coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
  • Sequence similaritiesBelongs to the COPE family.
  • Post-translational
    modifications
    Phosphorylated by PKA.
    Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.
  • Cellular localizationCytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
  • Information by UniProt
  • Database links
  • Alternative names
    • 1110005D17Rik antibody
    • Coatomer epsilon subunit antibody
    • Coatomer protein complex subunit epsilon antibody
    • Coatomer subunit epsilon antibody
    • COPE antibody
    • COPE_HUMAN antibody
    • Cope1 antibody
    • Epsilon coat protein antibody
    • Epsilon COP antibody
    • Epsilon COP I antibody
    • Epsilon subunit of coatomer protein complex antibody
    • Epsilon-coat protein antibody
    • Epsilon-COP antibody
    • FLJ13241 antibody
    see all

Anti-COPE antibody images

  • Anti-COPE antibody (ab88824) at 1/500 dilution + Human liver lysate at 25 µg

    Predicted band size : 34 kDa
    Observed band size : 34 kDa
  • All lanes : Anti-COPE antibody (ab88824) at 1/500 dilution

    Lane 1 : COPE transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 34 kDa
    Observed band size : 34 kDa

References for Anti-COPE antibody (ab88824)

This product has been referenced in:

See 1 Publication for this product

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