Anti-Coproporphyrinogen Oxidase (CPOX) antibody (ab102938)

Overview

  • Product name
    Anti-Coproporphyrinogen Oxidase (CPOX) antibody
    See all Coproporphyrinogen Oxidase (CPOX) primary antibodies
  • Description
    Rabbit polyclonal to Coproporphyrinogen Oxidase (CPOX)
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 425-454 of Human Coproporphyrinogen Oxidase (CPOX).

  • Positive control
    • Mouse liver tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab102938 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

Target

  • Function
    Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III.
  • Pathway
    Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
  • Involvement in disease
    Defects in CPOX are the cause of hereditary coproporphyria (HCP) [MIM:121300]. HCP is an acute hepatic porphyria and an autosomal dominant disease characterized by neuropsychiatric disturbances and skin photosensitivity. Biochemically, there is an overexcretion of coproporphyrin III in the urine and in the feces. HCP is clinically characterized by attacks of abdominal pain, neurological disturbances, and psychiatric symptoms. The symptoms are generally manifested with rapid onset, and can be precipitated by drugs, alcohol, caloric deprivation, infection, endocrine factors or stress. A severe variant form is harderoporphyria, which is characterized by earlier onset attacks, massive excretion of harderoporphyrin in the feces, and a marked decrease of coproporphyrinogen IX oxidase activity.
  • Sequence similarities
    Belongs to the aerobic coproporphyrinogen-III oxidase family.
  • Cellular localization
    Mitochondrion intermembrane space.
  • Information by UniProt
  • Database links
  • Alternative names
    • Coprogen oxidase antibody
    • COPROPORPHYRIA antibody
    • Coproporphyrinogen III oxidase antibody
    • Coproporphyrinogen-III oxidase antibody
    • Coproporphyrinogenase antibody
    • COX antibody
    • CPO antibody
    • Cpox antibody
    • CPX antibody
    • HEM 6 antibody
    • Hem-6 antibody
    • Hem6 antibody
    • HEM6_HUMAN antibody
    • mitochondrial antibody
    see all

Images

  • Anti-Coproporphyrinogen Oxidase (CPOX) antibody (ab102938) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

    Predicted band size : 50 kDa

References

ab102938 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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