Overview

  • Product name
  • Description
    Rabbit polyclonal to COPS3
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Xenopus laevis, Chimpanzee, Rhesus monkey, Orangutan, Platypus
  • Immunogen

    Synthetic peptide, corresponding to a region within the amino acids 325-375 of Human COPS3, NP_003644.2

  • Positive control
    • Human prostate adenocarcinoma. Human small cell lung cancer.

Properties

Applications

Our Abpromise guarantee covers the use of ab84432 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    • Tissue specificity
      Widely expressed. Expressed at high level in heart and skeletal muscle.
    • Sequence similarities
      Belongs to the CSN3 family.
      Contains 1 PCI domain.
    • Cellular localization
      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Constitutive photomorphogenic homolog subunit 3 antibody
      • COP 9 (constitutive photomorphogenic) subunit 3 antibody
      • COP 9 complex homolog subunit 3 antibody
      • COP 9 complex S3 antibody
      • COP 9 complex subunit 3 antibody
      • COP 9 constitutive photomorphogenic homolog subunit 3 antibody
      • COP 9 homolog antibody
      • COP 9 signalosome complex subunit 3 antibody
      • COP 9 signalosome subunit 3 antibody
      • COP 9 subunit 3 antibody
      • COP9 (constitutive photomorphogenic) subunit 3 antibody
      • COP9 complex homolog subunit 3 antibody
      • COP9 complex S3 antibody
      • COP9 complex subunit 3 antibody
      • COP9 constitutive photomorphogenic homolog subunit 3 antibody
      • COP9 homolog antibody
      • COP9 signalosome complex subunit 3 antibody
      • COP9 signalosome subunit 3 antibody
      • COP9 subunit 3 antibody
      • COPS 3 antibody
      • cops3 antibody
      • CSN 3 antibody
      • CSN3 antibody
      • CSN3_HUMAN antibody
      • JAB 1 containing signalosome subunit 3 antibody
      • JAB1 containing signalosome subunit 3 antibody
      • JAB1-containing signalosome subunit 3 antibody
      • SGN 3 antibody
      • SGN3 antibody
      • Signalosome subunit 3 antibody
      see all

    Images

    • etection of Human COPS3 by Immunohistochemistry.
      Sample: FFPE section of Human prostate adenocarcinoma.
      Antibody: ab84432 used at a dilution of 1/250.
      Detection: DAB staining.
    • Detection of Human COPS3 by Immunohistochemistry.
      Sample: FFPE section of Human small cell lung cancer.
      Antibody: ab84432 used at a dilution of 1/250.
      Detection: DAB staining.

    References

    ab84432 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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