Overview

  • Product name
  • Description
    Rabbit polyclonal to COPS7A
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human COPS7A.
    Database link: Q9UBW8

  • Positive control
    • HeLa, Raw264.7 and PC12 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab192381 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 30 kDa.

Target

  • Function
    Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • Tissue specificity
    Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
  • Sequence similarities
    Belongs to the CSN7/EIF3M family. CSN7 subfamily.
    Contains 1 PCI domain.
  • Post-translational
    modifications
    Phosphorylated by CK2 and PKD kinases.
  • Cellular localization
    Cytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • COP9 complex subunit 7a antibody
    • COP9 constitutive photomorphogenic homolog subunit 7A antibody
    • COP9 signalosome complex subunit 7a antibody
    • COP9 signalosome subunit 7A antibody
    • COPS7A antibody
    • CSN7A antibody
    • CSN7A_HUMAN antibody
    • Dermal papilla derived protein 10 antibody
    • Dermal papilla-derived protein 10 antibody
    • DERP10 antibody
    • JAB1 containing signalosome subunit 7a antibody
    • JAB1-containing signalosome subunit 7a antibody
    • SGN7a antibody
    • Signalosome subunit 7a antibody
    see all

Images

  • All lanes : Anti-COPS7A antibody (ab192381)

    Lane 1 : Hela cell lysate
    Lane 2 : Raw264.7 cell lysate
    Lane 3 : PC12 cell lysate

    Predicted band size: 30 kDa

References

ab192381 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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