Overview

  • Product nameAnti-COPS8 antibody
    See all COPS8 primary antibodies
  • Description
    Rabbit polyclonal to COPS8
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to a 15 amino acid peptide near the carboxy terminus of Human COPS8 (NP_006701).

  • Positive control
    • Human liver lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab106560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 23 kDa.

Target

  • FunctionComponent of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
  • Sequence similaritiesBelongs to the CSN8 family.
    Contains 1 PCI domain.
  • Cellular localizationCytoplasm. Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • COP9 homolog antibody
    • COP9 signalosome complex subunit 8 antibody
    • COP9 signalosome subunit 8 antibody
    • Cops8 antibody
    • CSN8 antibody
    • CSN8_HUMAN antibody
    • hCOP9 antibody
    • JAB1 containing signalosome subunit 8 antibody
    • JAB1-containing signalosome subunit 8 antibody
    • SGN8 antibody
    • Signalosome subunit 8 antibody
    see all

Anti-COPS8 antibody images

  • Anti-COPS8 antibody (ab106560) at 2 µg/ml + Human liver lysate at 15 µg

    Predicted band size : 23 kDa

References for Anti-COPS8 antibody (ab106560)

ab106560 has not yet been referenced specifically in any publications.

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