• Product name
  • Description
    Rabbit polyclonal to COPZ1
  • Tested applications
    Suitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal sequence of human COPZ1.

  • Positive control
    • Human cervix carcinoma tissue. Jurkat and COS cell extracts.



Our Abpromise guarantee covers the use of ab74370 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/10000.
WB 1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).
IHC-P 1/50 - 1/100.


  • Function
    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
    The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
  • Sequence similarities
    Belongs to the adaptor complexes small subunit family.
  • Post-translational
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm. Golgi apparatus membrane. Cytoplasmic vesicle > COPI-coated vesicle membrane. The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5930435A22Rik antibody
    • AA407760 antibody
    • CGI 120 antibody
    • Coatomer protein complex subunit zeta 1 antibody
    • Coatomer subunit zeta 1 antibody
    • Coatomer subunit zeta-1 antibody
    • COPZ antibody
    • COPZ 1 antibody
    • COPZ1 antibody
    • COPZ1_HUMAN antibody
    • D4Ertd360e antibody
    • HSPC181 antibody
    • MGC118060 antibody
    • Zeta 1 coat protein antibody
    • zeta 1 COP antibody
    • zeta COP antibody
    • Zeta-1 COP antibody
    • Zeta-1-coat protein antibody
    • Zeta1 COP antibody
    see all


  • ab74370 at 1/50 dilution staining COPZ1 in human cervix carcinoma by Immunohistochemistry using paraffin-embedded tissue, in the absence or presence of the immunising peptide.
  • All lanes : Anti-COPZ1 antibody (ab74370) at 1/500 dilution

    Lane 1 : Jurkat cell extracts
    Lane 2 : COS cell extracts
    Lane 3 : Jurkat cell extracts with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 20 kDa
    Observed band size : 20 kDa
    Additional bands at : 28 kDa,36 kDa,47 kDa,82 kDa. We are unsure as to the identity of these extra bands.


ab74370 has not yet been referenced specifically in any publications.

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