Overview

  • Product nameAnti-COQ2 antibody
    See all COQ2 primary antibodies
  • Description
    Rabbit polyclonal to COQ2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cat, Dog, Pig, Saccharomyces cerevisiae, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptide within residues: SGVMWTLIYD TIYAHQDKRD DVLIGLKSTA LRFGENTKPW LSGFSVAMLG, corresponding to internal sequence amino acids 252-301 of Human COQ2 (NP_056512)

  • Positive control
    • DU145 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab89706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 40 kDa.Can be blocked with COQ2 peptide (ab175788). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionCatalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.
  • Tissue specificityWidely expressed. Present in all of the tissues tested. Expressed at higher level in skeletal muscle, adrenal glands and the heart.
  • PathwayCofactor biosynthesis; ubiquinone biosynthesis.
  • Involvement in diseaseDefects in COQ2 are the cause of coenzyme Q10 deficiency, primary, type 1 (COQ10D1) [MIM:607426]. An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form.
  • Sequence similaritiesBelongs to the UbiA prenyltransferase family.
  • Cellular localizationMitochondrion membrane.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • 2310002F18Rik antibody
    • 4-hydroxybenzoate polyprenyltransferase antibody
    • CL640 antibody
    • Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase antibody
    • Coenzyme Q2 homolog, prenyltransferase (yeast) antibody
    • COQ10D1 antibody
    • COQ2 antibody
    • COQ2 homolog antibody
    • COQ2_HUMAN antibody
    • FLJ13014 antibody
    • FLJ26072 antibody
    • hCOQ2 antibody
    • MGC124824 antibody
    • MGC91278 antibody
    • mitochondrial antibody
    • MSA1 antibody
    • OTTMUSP00000032111 antibody
    • Para-hydroxybenzoate--polyprenyltransferase antibody
    • Para-hydroxybenzoate--polyprenyltransferase, mitochondrial antibody
    • PHB:polyprenyltransferase antibody
    • RGD1306722 antibody
    see all

Anti-COQ2 antibody images

  • Anti-COQ2 antibody (ab89706) at 1 µg/ml + DU145 cell lysate at 10 µg

    Secondary
    anti-Rabbit IgG HRP at 1/50000 dilution

    Predicted band size : 40 kDa
    Observed band size : 40 kDa

References for Anti-COQ2 antibody (ab89706)

ab89706 has not yet been referenced specifically in any publications.

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