Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab175788 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-COQ2 antibody (ab89706)

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at -20°C.

    Information available upon request.

General Info

  • Alternative names
    • 2310002F18Rik
    • 4-hydroxybenzoate polyprenyltransferase
    • CL640
    • Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
    • Coenzyme Q2 homolog, prenyltransferase (yeast)
    • COQ10D1
    • COQ2
    • COQ2 homolog
    • COQ2_HUMAN
    • FLJ13014
    • FLJ26072
    • hCOQ2
    • MGC124824
    • MGC91278
    • mitochondrial
    • MSA1
    • OTTMUSP00000032111
    • Para-hydroxybenzoate--polyprenyltransferase
    • Para-hydroxybenzoate--polyprenyltransferase, mitochondrial
    • PHB:polyprenyltransferase
    • RGD1306722
    see all
  • Function
    Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.
  • Tissue specificity
    Widely expressed. Present in all of the tissues tested. Expressed at higher level in skeletal muscle, adrenal glands and the heart.
  • Pathway
    Cofactor biosynthesis; ubiquinone biosynthesis.
  • Involvement in disease
    Defects in COQ2 are the cause of coenzyme Q10 deficiency, primary, type 1 (COQ10D1) [MIM:607426]. An autosomal recessive disorder with variable manifestations consistent with 5 major phenotypes. The phenotypes include an encephalomyopathic form with seizures and ataxia; a multisystem infantile form with encephalopathy, cardiomyopathy and renal failure; a predominantly cerebellar form with ataxia and cerebellar atrophy; Leigh syndrome with growth retardation; and an isolated myopathic form.
  • Sequence similarities
    Belongs to the UbiA prenyltransferase family.
  • Cellular localization
    Mitochondrion membrane.
  • Information by UniProt

References

ab175788 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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