The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 120, 250 kDa (predicted molecular weight: 116 kDa).
Use a concentration of 2 - 5 µg/ml.
Use a concentration of 0.01 - 0.1 µg/ml.
Use a concentration of 2 - 10 µg/ml.
FunctionSerine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
Tissue specificityHighly expressed in heart. Expressed in heart myocytes.
Sequence similaritiesBelongs to the peptidase S1 family. Contains 2 FZ (frizzled) domains. Contains 7 LDL-receptor class A domains. Contains 1 peptidase S1 domain. Contains 1 SRCR domain.
Post-translational modificationsN-glycosylated; required for processing and activation. Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. A disulfide bond links the N-terminal propeptide and the activated corin protease fragment.