• Product nameAnti-Corin antibody
    See all Corin primary antibodies
  • Description
    Rabbit polyclonal to Corin
  • Tested applicationsSuitable for: WB, IP, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 60-150 of Mouse Corin.

  • Positive control
    • Whole cell lysates derived from Mouse heart and Rat heart



Our Abpromise guarantee covers the use of ab125254 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 120, 250 kDa (predicted molecular weight: 116 kDa).
IP Use a concentration of 2 - 5 µg/ml.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.
IHC-P Use a concentration of 2 - 10 µg/ml.


  • FunctionSerine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
  • Tissue specificityHighly expressed in heart. Expressed in heart myocytes.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 FZ (frizzled) domains.
    Contains 7 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
  • Post-translational
    N-glycosylated; required for processing and activation.
    Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment.
    A disulfide bond links the N-terminal propeptide and the activated corin protease fragment.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • activated protease fragment antibody
    • ATC 2 antibody
    • ATC2 antibody
    • Atrial natriuretic peptide-converting enzyme antibody
    • Atrial natriuteric peptide converting enzyme antibody
    • Corin antibody
    • Corin serine peptidase antibody
    • CORIN_HUMAN antibody
    • CRN antibody
    • Heart specific serine proteinase antibody
    • Heart specific serine proteinase ATC2 antibody
    • Heart-specific serine proteinase ATC2 antibody
    • Lrp 4 antibody
    • Lrp4 antibody
    • MGC119742 antibody
    • Pro ANP convertase antibody
    • Pro ANP converting enzyme antibody
    • Pro-ANP-converting enzyme antibody
    • TMPRSS 10 antibody
    • TMPRSS10 antibody
    • Transmembrane protease serine 10 antibody
    see all

Anti-Corin antibody images

  • All lanes : Anti-Corin antibody (ab125254) at 1/500 dilution

    Lane 1 : Mouse heart whole cell lysates
    Lane 2 : Rat heart whole cell lysates

    Predicted band size : 116 kDa
    Observed band size : 120 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 205 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Corin antibody (ab125254)

ab125254 has not yet been referenced specifically in any publications.

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