Anti-Corin antibody (ab230311)
Key features and details
- Rabbit polyclonal to Corin
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Overview
-
Product name
Anti-Corin antibody
See all Corin primary antibodies -
Description
Rabbit polyclonal to Corin -
Host species
Rabbit -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Recombinant fragment corresponding to Human Corin aa 1-110.
Database link: Q9Y5Q5 -
Positive control
- WB: Rat heart tissue; Mouse liver tissue; HepG2 whole cell lysate. IHC-P: Human heart tissue.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab230311 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/1000 - 1/5000. Predicted molecular weight: 117, 114 kDa.
|
|
IHC-P |
1/20 - 1/200.
|
Notes |
---|
WB
1/1000 - 1/5000. Predicted molecular weight: 117, 114 kDa. |
IHC-P
1/20 - 1/200. |
Target
-
Function
Serine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide. -
Tissue specificity
Highly expressed in heart. Expressed in heart myocytes. -
Sequence similarities
Belongs to the peptidase S1 family.
Contains 2 FZ (frizzled) domains.
Contains 7 LDL-receptor class A domains.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain. -
Post-translational
modificationsN-glycosylated; required for processing and activation.
Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment.
A disulfide bond links the N-terminal propeptide and the activated corin protease fragment. -
Cellular localization
Cell membrane. - Information by UniProt
-
Database links
- Entrez Gene: 10699 Human
- Entrez Gene: 53419 Mouse
- Entrez Gene: 289596 Rat
- Omim: 605236 Human
- SwissProt: Q9Y5Q5 Human
- SwissProt: Q9Z319 Mouse
- SwissProt: Q80YN4 Rat
- Unigene: 518618 Human
see all -
Alternative names
- activated protease fragment antibody
- ATC 2 antibody
- ATC2 antibody
see all
Images
-
All lanes : Anti-Corin antibody (ab230311) at 1/1000 dilution
Lane 1 : Rat heart tissue
Lane 2 : Mouse liver tissue
Lane 3 : HepG2 (human liver hepatocellular carcinoma cell line) whole cell lysate
Secondary
All lanes : Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 117, 114 kDa
Observed band size: 116,28,36,45,49 kDa why is the actual band size different from the predicted? -
Paraffin-embedded human heart tissue stained for Corin using ab230311 at 1/100 dilution in immunohistochemical analysis.
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab230311 has not yet been referenced specifically in any publications.