The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
FunctionSerine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
Tissue specificityHighly expressed in heart. Expressed in heart myocytes.
Sequence similaritiesBelongs to the peptidase S1 family. Contains 2 FZ (frizzled) domains. Contains 7 LDL-receptor class A domains. Contains 1 peptidase S1 domain. Contains 1 SRCR domain.
Post-translational modificationsN-glycosylated; required for processing and activation. Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. A disulfide bond links the N-terminal propeptide and the activated corin protease fragment.
Western blot against tagged recombinant protein immunogen using ab56983 LRP4 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
References for Anti-Corin antibody (ab56983)
This product has been referenced in:
Tarazón E et al. RNA sequencing analysis and atrial natriuretic peptide production in patients with dilated and ischemic cardiomyopathy. PLoS One9:e90157 (2014).
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