Overview

  • Product nameAnti-Corin antibody
    See all Corin primary antibodies
  • Description
    Mouse monoclonal to Corin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: CKERDLWECP SNKQCLKHTV ICDGFPDCPD YMDEKNCSFC QDDELECANH ACVSRDLWCD GEADCSDSSD EWDCVTLSIN VNSSSFLMVH RAATEHHVCA , corresponding to amino acids 616-716 of Human LRP4

Properties

Applications

Our Abpromise guarantee covers the use of ab56983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Target

  • FunctionSerine-type endopeptidase involved in atrial natriuretic peptide hormone processing. Converts through proteolytic cleavage the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. May also process pro-NPPB the B-type natriuretic peptide.
  • Tissue specificityHighly expressed in heart. Expressed in heart myocytes.
  • Sequence similaritiesBelongs to the peptidase S1 family.
    Contains 2 FZ (frizzled) domains.
    Contains 7 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
    Contains 1 SRCR domain.
  • Post-translational
    modifications
    N-glycosylated; required for processing and activation.
    Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment.
    A disulfide bond links the N-terminal propeptide and the activated corin protease fragment.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • activated protease fragment antibody
    • ATC 2 antibody
    • ATC2 antibody
    • Atrial natriuretic peptide-converting enzyme antibody
    • Atrial natriuteric peptide converting enzyme antibody
    • Corin antibody
    • Corin serine peptidase antibody
    • CORIN_HUMAN antibody
    • CRN antibody
    • Heart specific serine proteinase antibody
    • Heart specific serine proteinase ATC2 antibody
    • Heart-specific serine proteinase ATC2 antibody
    • Lrp 4 antibody
    • Lrp4 antibody
    • MGC119742 antibody
    • Pro ANP convertase antibody
    • Pro ANP converting enzyme antibody
    • Pro-ANP-converting enzyme antibody
    • TMPRSS 10 antibody
    • TMPRSS10 antibody
    • Transmembrane protease serine 10 antibody
    see all

Anti-Corin antibody images

  • Western blot against tagged recombinant protein immunogen using ab56983 LRP4 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

References for Anti-Corin antibody (ab56983)

This product has been referenced in:
  • Tarazón E  et al. RNA sequencing analysis and atrial natriuretic peptide production in patients with dilated and ischemic cardiomyopathy. PLoS One 9:e90157 (2014). WB ; Human . Read more (PubMed: 24599027) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"