Overview

  • Product nameAnti-Corneodesmosin antibody
    See all Corneodesmosin primary antibodies
  • Description
    Rabbit polyclonal to Corneodesmosin
  • Tested applicationsSuitable for: WB, IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide derived from Nter domain of human CDSN

Properties

Applications

Our Abpromise guarantee covers the use of ab118835 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 51 kDa.
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.

Target

  • FunctionImportant for the epidermal barrier integrity.
  • Tissue specificityExclusively expressed in skin.
  • Involvement in diseaseDefects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
    Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.
  • Cellular localizationSecreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
  • Information by UniProt
  • Database links
  • Alternative names
    • AI747712 antibody
    • CDSN antibody
    • CDSN_HUMAN antibody
    • Corneodesmosin antibody
    • D6S586E antibody
    • DADB-141O4.5 antibody
    • Differentiated keratinocyte S protein antibody
    • HTSS antibody
    • S antibody
    • S protein antibody
    see all

References for Anti-Corneodesmosin antibody (ab118835)

ab118835 has not yet been referenced specifically in any publications.

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