Overview

  • Product nameAnti-Corneodesmosin antibody
    See all Corneodesmosin primary antibodies
  • Description
    Mouse monoclonal to Corneodesmosin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment: YLVPGMTYSK GKIYPVGYFT KENPVKGSPG VPSFAAGPPI SEGKYFSSNP , corresponding to amino acids 306-356 of Human Corneodesmosin

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2a
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab54852 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImportant for the epidermal barrier integrity.
    • Tissue specificityExclusively expressed in skin.
    • Involvement in diseaseDefects in CDSN are a cause of hypotrichosis simplex of the scalp (HTSS) [MIM:146520]; also known as hypotrichosis Spanish type. HTSS is an autosomal dominant form of isolated alopecia. Affected individuals have normal hair in early childhood but experience progressive loss of scalp hair beginning in the middle of the first decade and almost complete baldness by the third decade.
      Defects in CDSN are the cause of peeling skin syndrome type B (BPSS) [MIM:270300]; also known as peeling skin syndrome or deciduous skin or keratolysis exfoliativa congenita. BPSS is a genodermatosis characterized by the continuous shedding of the outer layers of the epidermis, associated with pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly thereafter. Several patients have been reported with high IgE levels.
    • Cellular localizationSecreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI747712 antibody
      • CDSN antibody
      • CDSN_HUMAN antibody
      • Corneodesmosin antibody
      • D6S586E antibody
      • DADB-141O4.5 antibody
      • Differentiated keratinocyte S protein antibody
      • HTSS antibody
      • S antibody
      • S protein antibody
      see all

    Anti-Corneodesmosin antibody images

    • Western blot against tagged recombinant protein immunogen using ab54852 Corneodesmosin antibody at 1ug/ml. Predicted band size of immunogen is 32 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    References for Anti-Corneodesmosin antibody (ab54852)

    ab54852 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab54852.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"