Overview

  • Product nameAnti-Cornulin antibody
  • Description
    Rabbit polyclonal to Cornulin
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide corresponding to a region within internal amino acids 431 - 480 (GDRQPTVVGE EWVDDHSRET VILRLDQGNL HTSVSSAQGQ DAAQSEEKRG) of Human Cornulin (NP_057274).

  • Positive control
    • HT1080 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab104675 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 54 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionSurvival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.
  • Tissue specificitySquamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR).
  • Sequence similaritiesBelongs to the S100-fused protein family.
    Contains 1 EF-hand domain.
  • DomainThe EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA.
  • Cellular localizationCytoplasm. Does not colocalize with TGM1.
  • Information by UniProt
  • Database links
  • Alternative names
    • 53 kDa putative calcium binding protein antibody
    • 53 kDa putative calcium-binding protein antibody
    • 53 kDa squamous epithelial induced stress protein antibody
    • 53 kDa squamous epithelial-induced stress protein antibody
    • 58 kDa heat shock protein antibody
    • C1orf10 antibody
    • Chromosome 1 open reading frame 10 antibody
    • Cornulin antibody
    • CRNN antibody
    • CRNN_HUMAN antibody
    • DRC1 antibody
    • PDRC1 antibody
    • SEP53 antibody
    • Squamous epithelial heat shock protein 53 antibody
    • Tumor related protein antibody
    • Tumor-related protein antibody
    see all

Anti-Cornulin antibody images

  • Anti-Cornulin antibody (ab104675) at 1 µg/ml + HT1080 cell lysate at 10 µg

    Predicted band size : 54 kDa

References for Anti-Cornulin antibody (ab104675)

ab104675 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab104675.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"