Overview

  • Product name
  • Description
    Rabbit polyclonal to Coronin 1a
  • Tested applications
    Suitable for: WB, ICC, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Cat, Human
  • Immunogen

    Recombinant Human Coronin 1a, expressed in and purified from E. coli.

  • Positive control
    • Mixed neuron/glial culture from newborn rat brain; HL60 cell extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab123574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/20000. Predicted molecular weight: 51 kDa.
ICC 1/5000. Using ABC or other enzyme linked immunocytochemical procedures.
ICC/IF 1/500 - 1/1000.

Target

  • Function
    May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
  • Tissue specificity
    Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
  • Sequence similarities
    Belongs to the WD repeat coronin family.
    Contains 7 WD repeats.
  • Cellular localization
    Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Cytoplasmic vesicle > phagosome membrane. In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
  • Information by UniProt
  • Database links
  • Alternative names
    • Actin binding protein antibody
    • CLABP antibody
    • Clipin A antibody
    • Clipin-A antibody
    • CLIPINA antibody
    • COR1A_HUMAN antibody
    • CORO1A antibody
    • Coronin 1 antibody
    • Coronin actin binding protein 1A antibody
    • Coronin like protein A antibody
    • Coronin like protein p57 antibody
    • Coronin-1A antibody
    • Coronin-like protein A antibody
    • Coronin-like protein p57 antibody
    • FLJ41407 antibody
    • HCORO1 antibody
    • MGC117380 antibody
    • OTTHUMP00000163017 antibody
    • p57 antibody
    • TACO antibody
    • Tryptophan aspartate containing coat protein antibody
    • Tryptophan aspartate-containing coat protein antibody
    see all

Images

  • ab123574, at 1/10000, staining Coronin 1a (green) in a mixed neuron/glial culture from newborn rat brain, by immunocytochemistry. Red staining is from an anti-Vimentin antibody, while blue is a nuclear DNA counter stain.
  • Anti-Coronin 1a antibody (ab123574) at 1/10000 dilution + HL60 Cell extract

    Predicted band size : 51 kDa

References

ab123574 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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