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Rabbit polyclonal to Cortactin
Mouse, Rat, Chicken, Human
Synthetic peptide conjugated to KLH, corresponding to amino acids 361-380 of Human Cortactin.
A431 cell line and NIH3T3 cell line.
If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Working dilutions should be discarded if not used within 12 hours.
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Preservative: 15mM Sodium Azide
Constituents: 0.01M PBS, pH 7.4
Concentration information loading...
Whole antiserum is fractionated and then further purified by ion-exchange
chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 65-75 kDa.
Use at an assay dependent dilution.
Contributes to the organization of the actin cytoskeleton and cell structure. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases.
Contains 7 cortactin repeats.
Contains 1 SH3 domain.
The SH3 motif may mediate binding to the cytoskeleton.
Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.
Cytoplasm > cytoskeleton. Cell projection > lamellipodium. Cell projection > ruffle. Associated with membrane ruffles and lamellipodia.
Information by UniProt
EMS 1 antibody
References for Anti-Cortactin antibody (ab11066)
This product has been referenced in:
et al. Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity. Exp Cell Res 317:195-209 (2011).
Read more (PubMed: 20951132) »
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"