Anti-Corticotropin Releasing Factor antibody [5D5] (ab10035)

Overview

  • Product nameAnti-Corticotropin Releasing Factor antibody [5D5]
    See all Corticotropin Releasing Factor primary antibodies
  • Description
    Mouse monoclonal [5D5] to Corticotropin Releasing Factor
  • SpecificityMoAb 5D5 reacts with human corticoliberin with Kd=3.6 x 10-10M (native) and 1.1 x 10-10M (denaturated).
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human) conjugated to BSA.

  • General notesConcentration varies from lot to lot and can be provided on request.


    Corticotropin Releasing Factor (Corticoliberin) is a hormone secreted from the hypothalamus. Its function is regulation of corticotropin release from the pituitary gland. The protein belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesPurity tested by electrophoresis.
  • Primary antibody notesCorticotropin Releasing Factor (Corticoliberin) is a hormone secreted from the hypothalamus. Its function is regulation of corticotropin release from the pituitary gland. The protein belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
  • ClonalityMonoclonal
  • Clone number5D5
  • MyelomaSp2/0
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab10035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.

Target

  • RelevanceCRF precursor is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRF is a neuroendocrine hormone secreted by the paraventricular nucleus (PVN) of the hypothalamus and is a key player in the hypothalamic pituitary adrenal axis. It is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. Neuronal CRF is important in a variety of diverse roles including, memory, depression, stress, kidney function, parturition, metabolism and feeding (to mention a few).
  • Cellular localizationCytoplasmic and Secreted
  • Database links
  • Alternative names
    • Corticoliberin antibody
    • Corticotropin releasing factor antibody
    • Corticotropin releasing hormone antibody
    • CRF antibody
    • Crh antibody
    • CRH1 antibody
    see all

References for Anti-Corticotropin Releasing Factor antibody [5D5] (ab10035)

ab10035 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"