Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-Corticotropin Releasing Factor antibody
See all Corticotropin Releasing Factor products (8) ...
Description
Rabbit polyclonal to Corticotropin Releasing Factor
Specificity
This antibody blocks specifically with the ovine CRF sequence that it was raised against. Cells and fibres are found in the paraventricular hypothalamic nucleus of rat brain in colchicine treated 4% FA perfused tissue.
Tested applications
IHC-Frmore details
Cross reactivity
Reacts with
Rat, Sheep, Human
Predicted to work with
Mouse, Chicken, Cow, Dog, Pig
Immunogen
Synthetic peptide: SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDI A, corresponding to amino acids 148-188 of Sheep CRF.
SQEPPISLDL TFHLLREVLE MTKADQLAQQ AHSNRKLLDI A
General notes
This product should be stored undiluted.
Should this product contain a precipitate we recommend microcentrifugation before use.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS, Whole Serum.
Purity
Whole antiserum
Primary antibody notes
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Endocrine system >> Hypothalamic pituitary adrenal axis
Signal Transduction >> Growth Factors/Hormones >> Hormones
Applications
Show applications key
Our Abpromise guarantee covers the use of ab11133 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr
IHC-Fr: 1/500 - 1/7500.IHC-Fr: 1/500 - 1/7500.
Target
Relevance
CRF precursor is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRF is a neuroendocrine hormone secreted by the paraventricular nucleus (PVN) of the hypothalamus and is a key player in the hypothalamic pituitary adrenal axis. It is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. Neuronal CRF is important in a variety of diverse roles including, memory, depression, stress, kidney function, parturition, metabolism and feeding (to mention a few).
Cellular localization
Secreted
Alternative names
- Corticoliberin antibody
- Corticotropin releasing factor antibody
- corticotropin releasing hormone antibody
see all
Database links
- Entrez Gene: 280755 Cow
- Entrez Gene: 1392 Human
- Entrez Gene: 12918 Mouse
- Entrez Gene: 81648 Rat
- Omim: 122560 Human
- SwissProt: Q703P0 Chicken
- SwissProt: Q95MI6 Cow
- SwissProt: P06850 Human
see all
References for Anti-Corticotropin Releasing Factor antibody (ab11133)
ab11133 has not yet been referenced specifically in any publications.
Publishing research using ab11133? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"