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Read our guarantee »Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Anti-Corticotropin Releasing Factor antibody
See all Corticotropin Releasing Factor products (8) ...
Rabbit polyclonal to Corticotropin Releasing Factor
This antibody blocks specifically with the ovine CRF sequence that it was raised against. Cells and fibres are found in the paraventricular hypothalamic nucleus of rat brain in colchicine treated 4% FA perfused tissue.
IHC-Frmore details
Reacts with
Rat, Sheep, Human
Predicted to work with
Mouse, Chicken, Cow, Dog, Pig
Synthetic peptide: SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDI A, corresponding to amino acids 148-188 of Sheep CRF.
SQEPPISLDL TFHLLREVLE MTKADQLAQQ AHSNRKLLDI A
Liquid
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.09% Sodium Azide
Constituents: PBS, Whole Serum.
Whole antiserum
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition
Polyclonal
IgG
Neuroscience >> Endocrine system >> Hypothalamic pituitary adrenal axis
Signal Transduction >> Growth Factors/Hormones >> Hormones
Our Abpromise guarantee covers the use of ab11133 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: 1/500 - 1/7500.
CRF precursor is a 41-amino acid peptide derived from a 196-amino acid preprohormone. CRF is a neuroendocrine hormone secreted by the paraventricular nucleus (PVN) of the hypothalamus and is a key player in the hypothalamic pituitary adrenal axis. It is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. Neuronal CRF is important in a variety of diverse roles including, memory, depression, stress, kidney function, parturition, metabolism and feeding (to mention a few).
Secreted
ab11133 has not yet been referenced specifically in any publications.
Publishing research using ab11133? Please let us know so that we can cite the reference in this datasheet
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