Anti-Cortisol antibody [CORT-2] (ab1952)

Overview

  • Product nameAnti-Cortisol antibody [CORT-2]
    See all Cortisol primary antibodies
  • Description
    Mouse monoclonal [CORT-2] to Cortisol
  • SpecificityCortisol-BSA conjugate and free cortisol. There is no cross-reactivity with BSA. CORT-2 does not bind with cortisone.
  • Tested applicationsSuitable for: competitive binding assaysmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein (Human) conjugated to BSA.

  • General notesConcentration varies from lot to lot and can be provided on request.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • Purification notesPurity tested by elcetrophoresis.
  • ClonalityMonoclonal
  • Clone numberCORT-2
  • MyelomaSp2/0
  • IsotypeIgG3
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab1952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
competitive binding assays Use at an assay dependent dilution.

Target

  • RelevanceCortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
  • Cellular localizationSecreted

Anti-Cortisol antibody [CORT-2] images

  • Cross-reactivity, % 50% displacement of cortisol-3-125-Iodine.

References for Anti-Cortisol antibody [CORT-2] (ab1952)

ab1952 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

To be honest we do not have an antibody that we have tested with this kind of novel assay, and therefore do not know if it would work nor can we guarantee it.

Although ab1949 may work, I may recommend ab...

Read More

Cross-reaction of cortisol antibodies with cortisone is the following: ab1949 - 0.6 %, ab1951 - 35 % and ab1952 - 0 %.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"