The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
FunctionMajor transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Tissue specificityPlasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
Involvement in diseaseDefects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
Sequence similaritiesBelongs to the serpin family.
Post-translational modificationsN-glycosylated; binds 5 oligosaccharide chains. Glycosylation in position Asn-260 is needed for steroid binding.
ab111075 at 6 µg/ml staining Cortisol Binding Globulin in formalin-fixed, paraffin-embedded Human Uterus by Immunohistochemistry. Detection utilised biotinylated
secondary antibody, alkaline phosphatase-streptavidin and
References for Anti-Cortisol Binding Globulin antibody (ab111075)
has not yet been referenced specifically in any publications.
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