Anti-Cortisol Binding Globulin antibody (ab111075)

Overview

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99.48% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111075 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionMajor transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
  • Tissue specificityPlasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
  • Involvement in diseaseDefects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
  • Sequence similaritiesBelongs to the serpin family.
  • Post-translational
    modifications
    N-glycosylated; binds 5 oligosaccharide chains.
    Glycosylation in position Asn-260 is needed for steroid binding.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • CBG antibody
    • CBG_HUMAN antibody
    • corticosteroid binding globulin antibody
    • Corticosteroid-binding globulin antibody
    • serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpin A6 antibody
    • serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpina6 antibody
    • Transcortin antibody
    see all

Anti-Cortisol Binding Globulin antibody images

  • ab111075 at 6 µg/ml staining Cortisol Binding Globulin in formalin-fixed, paraffin-embedded Human Uterus by Immunohistochemistry. Detection utilised biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-Cortisol Binding Globulin antibody (ab111075)

ab111075 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111075.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"