The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 45 kDa).
FunctionMajor transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Tissue specificityPlasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
Involvement in diseaseDefects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
Sequence similaritiesBelongs to the serpin family.
Post-translational modificationsN-glycosylated; binds 5 oligosaccharide chains. Glycosylation in position Asn-260 is needed for steroid binding.