Anti-Cortisol Binding Globulin antibody (ab113442)

Overview

  • Product name
    Anti-Cortisol Binding Globulin antibody
    See all Cortisol Binding Globulin primary antibodies
  • Description
    Goat polyclonal to Cortisol Binding Globulin
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide:

    KASQQINQHVKDKT

    by a Cysteine residue linker, corresponding to internal sequence amino acids 157-170 of Rat Cortisol Binding Globulin (NP_001009663.1)

  • Positive control
    • Rat Liver lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab113442 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 45 kDa).

Target

  • Function
    Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
  • Tissue specificity
    Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
  • Involvement in disease
    Defects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
  • Sequence similarities
    Belongs to the serpin family.
  • Post-translational
    modifications
    N-glycosylated; binds 5 oligosaccharide chains.
    Glycosylation in position Asn-260 is needed for steroid binding.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • CBG antibody
    • CBG_HUMAN antibody
    • corticosteroid binding globulin antibody
    • Corticosteroid-binding globulin antibody
    • serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpin A6 antibody
    • serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
    • Serpina6 antibody
    • Transcortin antibody
    see all

Images

  • Anti-Cortisol Binding Globulin antibody (ab113442) at 0.03 µg/ml + Rat Liver lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 45 kDa

References

ab113442 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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