Anti-Cortisol Binding Globulin antibody [EPR4615] (ab110648)

Overview

  • Product nameAnti-Cortisol Binding Globulin antibody [EPR4615]
    See all Cortisol Binding Globulin primary antibodies
  • Description
    Rabbit monoclonal [EPR4615] to Cortisol Binding Globulin
  • Tested applicationsSuitable for: WBmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human Cortisol Binding Globulin.

  • Positive control
    • Human fetal artery, plasma and placenta lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

Properties

Applications

Our Abpromise guarantee covers the use of ab110648 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 60 kDa (predicted molecular weight: 45 kDa).
  • Application notesIs unsuitable for ICC,IHC-P or IP.
  • Target

    • FunctionMajor transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
    • Tissue specificityPlasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.
    • Involvement in diseaseDefects in SERPINA6 are a cause of corticosteroid-binding globulin deficiency (CBG deficiency) [MIM:611489]. CBG deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo/hypertension and muscle fatigue.
    • Sequence similaritiesBelongs to the serpin family.
    • Post-translational
      modifications
      N-glycosylated; binds 5 oligosaccharide chains.
      Glycosylation in position Asn-260 is needed for steroid binding.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • CBG antibody
      • CBG_HUMAN antibody
      • corticosteroid binding globulin antibody
      • Corticosteroid-binding globulin antibody
      • serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
      • Serpin A6 antibody
      • serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 6 antibody
      • Serpina6 antibody
      • Transcortin antibody
      see all

    Anti-Cortisol Binding Globulin antibody [EPR4615] images

    • All lanes : Anti-Cortisol Binding Globulin antibody [EPR4615] (ab110648) at 1/1000 dilution

      Lane 1 : Human fetal artery lysate
      Lane 2 : Human plasma lysate
      Lane 3 : Human placenta lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 45 kDa
      Observed band size : 60 kDa (why is the actual band size different from the predicted?)

    References for Anti-Cortisol Binding Globulin antibody [EPR4615] (ab110648)

    ab110648 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"