Overview

  • Product name
    Anti-Cox-3 antibody
  • Description
    Rabbit polyclonal to Cox-3
  • Specificity
    ab37269 recognizes COX-3.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide corresponding to residues from the N-terminus of Cox-3 (Mouse).

  • Positive control
    • mouse small intestinal tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab37269 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 4 µg/ml. Predicted molecular weight: 30 kDa.

Target

  • Relevance
    COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences from COX-1 or COX-2, and without COX activity. COX-3 is thought to be a splice variant of COX-1 which retains intron one. It has been suggested that COX-3 may be the key to unlocking the mechanism of action of acetaminophen.
  • Cellular localization
    Membrane-associated; Microsomal membrane.
  • Database links
  • Alternative names
    • Cox3 antibody
    • Cyclooxygenase 1 antibody
    • Ptgs1 antibody

References

This product has been referenced in:
  • Cui TZ  et al. Modulation of the respiratory supercomplexes in yeast: enhanced formation of cytochrome oxidase increases the stability and abundance of respiratory supercomplexes. J Biol Chem 289:6133-41 (2014). WB ; Saccharomyces cerevisiae . Read more (PubMed: 24421313) »

See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab37269.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up