Overview

  • Product nameAnti-COX10 antibody
    See all COX10 primary antibodies
  • Description
    Mouse polyclonal to COX10
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-443 of Human COX10

  • Positive control
    • 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/500 - 1/1000. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa).
    Detection Antibody Pair.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionConverts protoheme IX and farnesyl diphosphate to heme O.
    • Involvement in diseaseDefects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
      Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
    • Sequence similaritiesBelongs to the ubiA prenyltransferase family.
    • Cellular localizationMitochondrion membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2410004F01Rik antibody
      • AU042636 antibody
      • COX10 antibody
      • COX10_HUMAN antibody
      • Cytochrome c oxidase assembly protein antibody
      • Cytochrome c oxidase subunit X antibody
      • Heme A farnesyltransferase antibody
      • Heme O synthase antibody
      • OTTMUSP00000006085 antibody
      • Protoheme IX farnesyltransferase, mitochondrial antibody
      • Protoheme IX farnesyltransferase, mitochondrial precursor antibody
      • RP23-78H18.1 antibody
      see all

    Anti-COX10 antibody images

    • All lanes : Anti-COX10 antibody (ab67197) at 1/500 dilution

      Lane 1 : COX10 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg/ml per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 48 kDa
      Observed band size : 48 kDa

    References for Anti-COX10 antibody (ab67197)

    ab67197 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab67197.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"