Overview

  • Product name
  • Description
    Rabbit polyclonal to COX15
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within internal amino acids 178-373 of Human COX15 (Q7KZN9).

  • Positive control
    • Human colon carcinoma tissue; Jurkat whole cell lysate.
  • General notes
    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab126111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 46 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Antigen retrieval using Tris-EDTA buffer ( PH8.0) also possible.

Target

  • Function
    May be involved in the biosynthesis of heme A.
  • Tissue specificity
    Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • Pathway
    Porphyrin metabolism; heme A biosynthesis; heme A from heme O: step 1/1.
  • Involvement in disease
    Defects in COX15 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
    Defects in COX15 are a cause of Leigh syndrome (LS) [MIM:256000]. An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.
  • Sequence similarities
    Belongs to the COX15/CtaA family.
  • Cellular localization
    Mitochondrion membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CEMCOX2 antibody
    • COX15 antibody
    • COX15 homolog, cytochrome c oxidase assembly protein antibody
    • COX15, S. cerevisiae, homolog of antibody
    • COX15_HUMAN antibody
    • cytochrome c oxidase assembly homolog 15 (yeast) antibody
    • Cytochrome c oxidase assembly protein COX15 homolog antibody
    • cytochrome c oxidase subunit 15 antibody
    see all

Images

  • Anti-COX15 antibody (ab126111) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size: 46 kDa



    10% SDS Page
  • ab126111, at a 1/250 dilution, staining COX15 in paraffin-embedded Human colon carcinoma tissue by immunohistochemistry.

References

ab126111 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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