General notesab94069 is a 293T cell transfected lysate in which Human COX2 / Cyclooxygenase 2 has been transiently over-expressed using a pCMV-COX2 / Cyclooxygenase 2 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more detailed how the transfected lysate was prepared view preparation notes
BackgroundFunction: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Pathway: Lipid metabolism; prostaglandin biosynthesis.
Similarity: Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.
PTM: S-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561.