Anti-Coxsackie Adenovirus Receptor antibody [2T6] (ab62497)


  • Product nameAnti-Coxsackie Adenovirus Receptor antibody [2T6]
    See all Coxsackie Adenovirus Receptor primary antibodies
  • Description
    Mouse monoclonal [2T6] to Coxsackie Adenovirus Receptor
  • Tested applicationsSuitable for: WB, ICCmore details
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse
  • Immunogen

    Native human Coxsackie Adenovirus Receptor protein

  • Positive control
    • CHO cells transfected with hCAR.



Our Abpromise guarantee covers the use of ab62497 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesICC: Use at a concentration of 1 - 2 µg/ml.
    Note: cells are fixed with 4% paraformaldehyde and premealised with 0.2% Triton X-100.
    WB: Use at a concentration of 0.2 - 2.0 µg/ml. Detects a band of approximately 46 kDa (predicted molecular weight: 41 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.
    • Tissue specificityExpressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
    • Sequence similaritiesContains 2 Ig-like C2-type (immunoglobulin-like) domains.
    • DomainThe Ig-like C2-type 1 domain probably mediates homodimerization and interaction with JAML.
      The PDZ-binding motif mediates interaction with MPDZ and BAIAP1.
    • Post-translational
      Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane.
    • Cellular localizationSecreted and Cell membrane. Cell junction > tight junction. Cell junction > adherens junction. Basolateral cell membrane. In epithelial cells localizes to the apical junction complex composced of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface.
    • Information by UniProt
    • Database links
    • Alternative names
      • 46 kD coxsackievirus and adenovirus receptor CAR protein antibody
      • 46 kD coxsackievirus and adenovirus receptor protein antibody
      • CAR antibody
      • CAR4/6 antibody
      • Coxsackie virus and adenovirus receptor antibody
      • Coxsackie virus B receptor antibody
      • Coxsackievirus and adenovirus receptor antibody
      • Coxsackievirus B adenovirus receptor antibody
      • Coxsackievirus B-adenovirus receptor antibody
      • CVB3 binding protein antibody
      • CVB3-binding protein antibody
      • Cxadr antibody
      • CXAR_HUMAN antibody
      • hCAR antibody
      • HCVADR antibody
      see all

    References for Anti-Coxsackie Adenovirus Receptor antibody [2T6] (ab62497)

    ab62497 has not yet been referenced specifically in any publications.

    Product Wall

    This antibody recognizes an epitope within the D1/D2 (extracellular Ig domains) of CAR.