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CP 94253 dihydrochloride
Highly potent, selective 5-HT
Highly potent and selective 5-HT
1B agonist (K i = 2.0 nM compared to values of 89 (5-HT 1A), 860 (5-HT 1C), 49 (5-HT 1D) and 1600 nM (5-HT 2)). Shows many behavioural effects, reducing aggression and food intake. Additionally, enhances cocaine reinforcement.
H-pyrrolo[3,2- b]pyridine dihydrochloride
15H 19N 3O.2HCl
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our
frequently asked questions (FAQ) page for more details.
References for CP 94253 dihydrochloride (ab120522)
This product has been referenced in:
et al. Stimulation of 5-HT(1B) receptors enhances cocaine reinforcement yet reduces cocaine-seeking behavior. Addict Biol 14:419-30 (2009).
Read more (PubMed: 19650818) »
et al. Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats. Braz J Med Biol Res 40:825-30 (2007).
Read more (PubMed: 17581682) »
Halford JC & Blundell JE
The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiol Behav 60:933-9 (1996).
Read more (PubMed: 8873272) »
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for this product
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"