Overview

  • Product name
    CP 94253 dihydrochloride
  • Description
    Highly potent, selective 5-HT1B agonist
  • Biological description
    Highly potent and selective 5-HT1B agonist (Ki = 2.0 nM compared to values of 89 (5-HT1A), 860 (5-HT1C), 49 (5-HT1D) and 1600 nM (5-HT2)). Shows many behavioural effects, reducing aggression and food intake. Additionally, enhances cocaine reinforcement.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Pentkowski NS  et al. Stimulation of 5-HT(1B) receptors enhances cocaine reinforcement yet reduces cocaine-seeking behavior. Addict Biol 14:419-30 (2009). Read more (PubMed: 19650818) »
  • Veiga CP  et al. Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats. Braz J Med Biol Res 40:825-30 (2007). Read more (PubMed: 17581682) »
  • Halford JC & Blundell JE The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence. Physiol Behav 60:933-9 (1996). Read more (PubMed: 8873272) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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