The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration.
FunctionInhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
Tissue specificityIsoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
Sequence similaritiesBelongs to the PP1 inhibitor family.