Recombinant
RabMAb

Anti-CPN1 antibody [EPR6229] (ab124874)

Overview

  • Product name
    Anti-CPN1 antibody [EPR6229]
    See all CPN1 primary antibodies
  • Description
    Rabbit monoclonal [EPR6229] to CPN1
  • Tested applications
    Suitable for: WB, ICC/IFmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human CPN1.

  • Positive control
    • Human plasma, HepG2 and Human fetal liver lysates
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab124874 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 55, 48, 27 kDa (predicted molecular weight: 52 kDa). Note: The 48-kDa form is generated by proteolytic cleavage at the C-terminus. This subunit is cleaved into a peptide
ICC/IF 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • Function
      Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
    • Tissue specificity
      Synthesized in the liver and secreted in plasma.
    • Involvement in disease
      Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.
    • Sequence similarities
      Belongs to the peptidase M14 family.
    • Cellular localization
      Secreted > extracellular space.
    • Information by UniProt
    • Database links
    • Alternative names
      • ACBP antibody
      • Anaphylatoxin inactivator antibody
      • Arginine carboxypeptidase antibody
      • Carboxypeptidase N catalytic chain antibody
      • Carboxypeptidase N polypeptide 1 50 kD antibody
      • Carboxypeptidase N polypeptide 1 antibody
      • Carboxypeptidase N small subunit antibody
      • Carboxypeptidase N subunit 1 antibody
      • CBPN_HUMAN antibody
      • CPN antibody
      • CPN1 antibody
      • Kininase 1 antibody
      • Kininase-1 antibody
      • Kininase1 antibody
      • Lysine carboxypeptidase antibody
      • Plasma carboxypeptidase B antibody
      • SCPN antibody
      • Serum carboxypeptidase N antibody
      see all

    Images

    • All lanes : Anti-CPN1 antibody [EPR6229] (ab124874) at 1/1000 dilution

      Lane 1 : Human plasma lysate
      Lane 2 : HepG2 lysate
      Lane 3 : Human fetal liver lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 52 kDa
      Additional bands at : 27 kDa (possible cleavage fragment),48 kDa (possible cleavage fragment).

    References

    ab124874 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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