Overview

  • Product name
    CPPG
  • Description
    Potent group II/III metabotropic glutamate receptor antagonist
  • Biological description
    Potent group II/III metabotropic glutamate receptor antagonist. Displays 20-fold selectivity for Group III over Group II. Ki values are 11.5, 17.3 and 4.02 μM for mGlu receptor subtypes mGlu6 mGlu7a and mGlu8a, respectively.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Wright RA  et al. Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol 362:546-54 (2000). Read more (PubMed: 11138847) »
  • Toms NJ  et al. The effects of (RS)-alpha-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. Br J Pharmacol 119:851-4 (1996). Read more (PubMed: 8922731) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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