Overview

  • Product name
    CRANAD-58
  • Description
    Near-infrared Amyloid-β fluorescent probe
  • Biological description

    Near-infrared (NIR) Amyloid-β fluorescent probe. Demonstrates different fluorescence response towards soluble and insoluble Aβ species. Significant fluorescence intensity increase (91.9-fold for Aβ40, 113.6-fold for Aβ42) and high affinity (Kd values are 105.8 nM and 45.8 nM for Aβ40 and Aβ42 respectively) for Aβ monomers observed. Detects soluble Aβ species in transgenic APP/PS1 mice at the age of 4 months. Learn more

  • Purity
    > 99%

Properties

  • Chemical name
    (T-4)-[(1E,6E)-1-[6-(Diethylamino)-3-pyridinyl]-7-[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoroboron
  • Molecular weight
    349.31
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C24H28BF2N3O2
  • PubChem identifier
    102219361
  • Storage instructions
    Shipped at 4°C. Store at -20°C long term. Store under desiccating conditions.
  • Solubility overview
    Soluble in DMSO to 10 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCN(CC)c1ccc(cn1)/C=C/C(=O)/C=C(/C=C/c2ccc(cc2)N(C)C)OB(F)F
  • Source

    Synthetic

References

This product has been referenced in:
  • Yang J  et al. Imaging hydrogen peroxide in Alzheimer's disease via cascade signal amplification. Sci Rep 6:35613 (2016). Read more (PubMed: 27762326) »
  • Staderini M  et al. Imaging of ß-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience. Chem Soc Rev 44:1807-19 (2015). Read more (PubMed: 25622714) »
  • Tong H  et al. Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer?s disease. Acta Pharm Sin B 5:25-33 (2015). Read more (PubMed: 26579421) »
  • Zhang X  et al. Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease. J Am Chem Soc 135:16397-409 (2013). Read more (PubMed: 24116384) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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