Overview

  • Product nameAnti-CRCP antibody
    See all CRCP primary antibodies
  • Description
    Rabbit polyclonal to CRCP
  • Tested applicationsSuitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    antigen sequence: TPCRHQSPEI VREFLTALKS HKLTKAEKLQ LLNHRPVTAV EIQLMVEESE ERLTEEQIEA LLHTVTSILP AEPEAEQKKN TNSNVAMDEE DPA, corresponding to amino acids 56-148 of Human CRCP.

  • Positive control
    • Human testis tissue; RT-4 and U-251 MG cell lysates.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab121255 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Perform Heat Induced Epitope Retrieval (HIER) at pH 6.
ICC/IF Use at an assay dependent concentration.

Target

  • FunctionDNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.
    Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
  • Tissue specificityUbiquitous. Most prevalent in testis.
  • Sequence similaritiesBelongs to the eukaryotic RPC9 RNA polymerase subunit family.
  • Cellular localizationNucleus. Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcitonin gene related peptide receptor component antibody
    • Calcitonin gene related peptide receptor component protein antibody
    • Calcitonin gene-related peptide-receptor component protein antibody
    • CGRP receptor component protein antibody
    • CGRP-RCP antibody
    • CGRP-receptor component protein antibody
    • CGRPRCP antibody
    • CRCP antibody
    • DNA-directed RNA polymerase III subunit RPC9 antibody
    • HsC17 antibody
    • RCP antibody
    • RCP9 antibody
    • RNA polymerase III subunit C9 antibody
    • RPC9_HUMAN antibody
    see all

Anti-CRCP antibody images

  • Immunofluorescent staining of human cell line A-431 shows positivity in nucleus.
  • ab121255, at 1/30 dilution, staining CRCP in paraffin-embedded Human testis by Immunohistochemistry showing cytoplasmic and nuclear positivity of cells in seminiferus ducts.

References for Anti-CRCP antibody (ab121255)

ab121255 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab121255.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"