Overview

  • Product nameAnti-CREB3L1 antibody
    See all CREB3L1 primary antibodies
  • Description
    Goat polyclonal to CREB3L1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    C-DFSHSKEWFHDRD

    , corresponding to C-terminal amino acids 497-509 of Human CREB3L1 (NP_443086.1).

  • Positive control
    • A549 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab109099 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 57 kDa.

Target

  • FunctionTranscription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
  • Tissue specificityUbiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
  • Sequence similaritiesBelongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • Post-translational
    modifications
    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
  • Cellular localizationEndoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BBF-2 homolog antibody
    • CAMP responsive element binding protein 3 like 1 antibody
    • cAMP-responsive element-binding protein 3-like protein 1 antibody
    • CR3L1_HUMAN antibody
    • Creb3l1 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 1 antibody
    • OASIS antibody
    • Old astrocyte specifically-induced substance antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody
    see all

Anti-CREB3L1 antibody images

  • Anti-CREB3L1 antibody (ab109099) at 3 µg/ml + A549 cell lysate
    Developed using the ECL technique

    Predicted band size : 57 kDa

References for Anti-CREB3L1 antibody (ab109099)

ab109099 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab109099.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"