Anti-CREB3L1 antibody - Carboxyterminal end (ab71778)

Overview

  • Product name
    Anti-CREB3L1 antibody - Carboxyterminal end
    See all CREB3L1 primary antibodies
  • Description
    Rabbit polyclonal to CREB3L1 - Carboxyterminal end
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Positive control
    • Formalin-fixed, paraffin-embedded human hepatocarcinoma tissue and A375 lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab71778 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 57 kDa (predicted molecular weight: 57 kDa).
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • Function
    Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
  • Tissue specificity
    Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
  • Sequence similarities
    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • Post-translational
    modifications
    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
  • Cellular localization
    Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BBF-2 homolog antibody
    • CAMP responsive element binding protein 3 like 1 antibody
    • cAMP-responsive element-binding protein 3-like protein 1 antibody
    • CR3L1_HUMAN antibody
    • Creb3l1 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 1 antibody
    • OASIS antibody
    • Old astrocyte specifically-induced substance antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody
    see all

Images

  • Anti-CREB3L1 antibody - Carboxyterminal end (ab71778) at 1/100 dilution + A375 lysate at 12.5 µg

    Predicted band size : 57 kDa
    Observed band size : 57 kDa
    Additional bands at : 30 kDa,60 kDa,90 kDa. We are unsure as to the identity of these extra bands.
  • Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ab71778 at a 1:50 dilution. A peroxidase-conjugated secondary antibody was then used, followed by DAB staining.

References

ab71778 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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