Overview

  • Product name
  • Description
    Rabbit polyclonal to CRLF2
  • Tested applications
    Suitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    KLH conjugated synthetic peptide of 19 amino acids in length from near the center of Human CRLF2.

  • Positive control
    • Human liver tissue, Human kidney tissue

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab109626 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.
  • Tissue specificity
    Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.
  • Sequence similarities
    Belongs to the type I cytokine receptor family. Type 5 subfamily.
    Contains 1 fibronectin type-III domain.
  • Domain
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is important for association with JAKs.
  • Cellular localization
    Secreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CRL 2 antibody
    • CRL2 antibody
    • CRLF 2 antibody
    • Crlf2 antibody
    • CRLF2_HUMAN antibody
    • CRLF2Y antibody
    • Cytokine receptor CRL2 precusor antibody
    • Cytokine receptor like 2 antibody
    • Cytokine receptor like factor 2 antibody
    • Cytokine receptor like factor 2 precursor antibody
    • Cytokine receptor-like 2 antibody
    • Cytokine receptor-like factor 2 antibody
    • IL XR antibody
    • IL-XR antibody
    • ILXR antibody
    • Thymic stromal derived lymphopoietin receptor antibody
    • Thymic stromal lymphopoietin protein receptor antibody
    • Thymic stromal lymphopoietin receptor antibody
    • TSLP receptor antibody
    • TSLPR antibody
    see all

Anti-CRLF2 antibody images

  • Lane 1 : Anti-CRLF2 antibody (ab109626) at 0.5 µg/ml
    Lane 2 : Anti-CRLF2 antibody (ab109626) at 1 µg/ml
    Lane 3 : Anti-CRLF2 antibody (ab109626) at 2 µg/ml

    Lane 1 : Human liver tissue lysate
    Lane 2 : Human liver tissue lysate
    Lane 3 : Human liver tissue lysate


    Predicted band size : 42 kDa
  • Human kidney tissue (formalin-fixed, paraffin-embedded) stained with ab109626 at a concentration of 5 µg/ml.
  • Human liver tissue (formalin-fixed, paraffin-embedded) stained with ab109626 at a concentration of 5 µg/ml.

References for Anti-CRLF2 antibody (ab109626)

ab109626 has not yet been referenced specifically in any publications.

Product Wall

ab109626 is raised against the extracellular portion of human CRLF2 according to uniprot (http://www.uniprot.org/uniprot/Q9HC73). The immunogenic peptide used to generate this antibody is located between amino acids 125 and 175 of Q9HC73. There is also...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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