Anti-CRMP2 antibody (ab36201)
Key features and details
- Rabbit polyclonal to CRMP2
- Suitable for: WB, IHC-Fr
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CRMP2 antibody
See all CRMP2 primary antibodies -
Description
Rabbit polyclonal to CRMP2 -
Host species
Rabbit -
Specificity
No cross reactivity was detected with CRMP1, CRMP3, CRMP4 or CRMP5. -
Tested applications
Suitable for: WB, IHC-Frmore details -
Species reactivity
Reacts with: Human -
Immunogen
A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab36201 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/2000. Predicted molecular weight: 63 kDa.
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IHC-Fr |
1/500.
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Notes |
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WB
1/2000. Predicted molecular weight: 63 kDa. |
IHC-Fr
1/500. |
Target
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Function
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. -
Tissue specificity
Ubiquitous. -
Sequence similarities
Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. -
Post-translational
modifications3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. -
Cellular localization
Cytoplasm. - Information by UniProt
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Database links
- Entrez Gene: 1808 Human
- Omim: 602463 Human
- SwissProt: Q16555 Human
- Unigene: 173381 Human
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Alternative names
- Collapsin response mediator protein 2 antibody
- Collapsin response mediator protein antibody
- Collapsin response mediator protein hCRMP 2 antibody
see all
Images
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All lanes : Anti-CRMP2 antibody (ab36201)
Lane 1 : E.coli transformed with cDNA of human CRMP1
Lane 2 : E.coli transformed with cDNA of human CRMP2
Lane 3 : E.coli transformed with cDNA of human CRMP3
Lane 4 : E.coli transformed with cDNA of human CRMP4
Lane 5 : E.coli transformed with cDNA of human CRMP5
Predicted band size: 63 kDa
Observed band size: 65 kDa why is the actual band size different from the predicted? -
Ab36201 staining human CRMP2 in olfactory receptor neurons within the olfactory mucosa by immunohistochemistry.
Protocols
Datasheets and documents
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Datasheet download
References (7)
ab36201 has been referenced in 7 publications.
- Simões AP et al. Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation. Cell Death Dis 9:297 (2018). PubMed: 29463792
- Sukumaran SK et al. Whole transcriptome profiling of taste bud cells. Sci Rep 7:7595 (2017). PubMed: 28790351
- Bajor M et al. Synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 are novel members of the matrix metalloproteinase-9 degradome. J Neurochem 122:775-88 (2012). PubMed: 22694054
- Mileusnic R & Rose SP The memory enhancing effect of the APP-derived tripeptide Ac-rER is mediated through CRMP2. J Neurochem 118:616-25 (2011). PubMed: 21255016
- Samara A et al. Proteomics reveal rat hippocampal lateral asymmetry. Hippocampus 21:108-19 (2011). WB ; Rat . PubMed: 20020437
- Gelman BB & Nguyen TP Synaptic proteins linked to HIV-1 infection and immunoproteasome induction: proteomic analysis of human synaptosomes. J Neuroimmune Pharmacol 5:92-102 (2010). WB ; Human . PubMed: 19693676
- Tumusiime S et al. Regulation of ROCKII by localization to membrane compartments and binding to DynaminI. Biochem Biophys Res Commun 381:393-6 (2009). PubMed: 19222995