Overview

  • Product nameAnti-CROCC antibody
    See all CROCC primary antibodies
  • Description
    Rabbit polyclonal to CROCC
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: LEAEKEELSE EIAALQQERD EGLLLAESEK QQALSLKESE KTALSEKLMG TRHSLATISL EMERQKRDAQ SRQEQDRSTV NALTSELRDL R, corresponding to amino acids 1031-1121 of Human CROCC

  • Positive control
    • Human fallopian tube tissue

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferpH: 7.20
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab121694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.

Target

  • FunctionMajor structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis.
  • Sequence similaritiesBelongs to the rootletin family.
  • Post-translational
    modifications
    Phosphorylated by NEK2 which may regulate its association with centrosomes. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > cytoskeleton > centrosome > centriole. In ciliated cells, associated with ciliary rootlets. In non-ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.
  • Information by UniProt
  • Database links
  • Alternative names
    • ciliary rootlet coiled coil antibody
    • Ciliary rootlet coiled-coil protein antibody
    • Crocc antibody
    • CROCC_HUMAN antibody
    • KIAA0445 antibody
    • Rootletin antibody
    see all

Anti-CROCC antibody images

  • Immunohistochemical staining of paraffin embedded Human fallopian tube tissue, using 1/4000 ab121694.

References for Anti-CROCC antibody (ab121694)

ab121694 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"