Overview

  • Product nameAnti-CRY2 antibody
    See all CRY2 primary antibodies
  • Description
    Rabbit polyclonal to CRY2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 158-207, IELNGQKPPL TYKRFQAIIS RMELPKKPVG LVTSQQMESC RAEIQENHDE, of Human CRY2 (NP_066940, Q49AN0).

  • Positive control
    • U937 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab102542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 67 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionBlue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK
    NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK
    NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
  • Tissue specificityExpressed in all tissues examined including fetal brain, fibroblasts, heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Highest levels in heart and skeletal muscle.
  • Sequence similaritiesBelongs to the DNA photolyase class-1 family.
    Contains 1 DNA photolyase domain.
  • Post-translational
    modifications
    Phosphorylation on Ser-266 by MAPK is important for the inhibition of CLOCK-ARNTL-mediated transcriptional activity. Phosphorylation by CSKNE requires interaction with PER1 or PER2.
    Ubiquitinated by the SCF(FBXL3) and SCF(FBXL21) complex, leading to its degradation.
  • Cellular localizationCytoplasm. Nucleus. Translocated to the nucleus through interaction with other Clock proteins such as PER2 or ARNTL.
  • Information by UniProt
  • Database links
  • Alternative names
    • cry2 antibody
    • CRY2_HUMAN antibody
    • cryptochrome 2 (photolyase like) antibody
    • Cryptochrome 2 antibody
    • Cryptochrome-2 antibody
    • FLJ10332 antibody
    • growth inhibiting protein 37 antibody
    • HCRY2 antibody
    • KIAA0658 antibody
    • PHLL2 antibody
    • Photolyase like antibody
    see all

Anti-CRY2 antibody images

  • Anti-CRY2 antibody (ab102542) at 1 µg/ml + U937 cell lysate at 10 µg

    Predicted band size : 67 kDa

References for Anti-CRY2 antibody (ab102542)

ab102542 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"