Overview

  • Product name
  • Description
    Mouse polyclonal to CRYGD
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein (Human), CRYGD (NP_008822.2, 174 a.a).

  • Positive control
    • CRYGD transfected 293T cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Protein G purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab69703 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 16 kDa (predicted molecular weight: 21 kDa).

Target

  • Function
    Crystallins are the dominant structural components of the vertebrate eye lens.
  • Involvement in disease
    Defects in CRYGD are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood.
    Defects in CRYGD are the cause of cataract congenital non-nuclear polymorphic autosomal dominant (CCP) [MIM:601286]; also known as polymorphic congenital cataract. A congenital cataract characterized by a non-progressive phenotype and partial opacity that has a variable location between the fetal nucleus of the lens and the equator. The fetal nucleus is normal. The opacities are irregular and look similar to a bunch of grapes and may be present simultaneously in different lens layers.
    Defects in CRYGD are the cause of cataract congenital cerulean type 3 (CCA3) [MIM:608983]; also known as congenital cataract blue dot type 3. A cerulean form of autosomal dominant congenital cataract. Cerulean cataract is characterized by peripheral bluish and white opacifications organized in concentric layers with occasional central lesions arranged radially. The opacities are observed in the superficial layers of the fetal nucleus as well as the adult nucleus of the lens. Involvement is usually bilateral. Visual acuity is only mildly reduced in childhood. In adulthood, the opacifications may progress, making lens extraction necessary. Histologically the lesions are described as fusiform cavities between lens fibers which contain a deeply staining granular material. Although the lesions may take on various colors, a dull blue is the most common appearance and is responsible for the designation cerulean cataract.
    Defects in CRYGD are the cause of cataract crystalline aculeiform (CACA) [MIM:115700]. A congenital crystalline cataract characterized by fiberglass-like or needle-like crystals projecting in different directions, through or close to the axial region of the lens. The opacity causes a variable degree of vision loss.
  • Sequence similarities
    Belongs to the beta/gamma-crystallin family.
    Contains 4 beta/gamma crystallin 'Greek key' domains.
  • Domain
    Has a two-domain beta-structure, folded into four very similar Greek key motifs.
  • Information by UniProt
  • Database links
  • Alternative names
    • CACA antibody
    • CCA3 antibody
    • CCP antibody
    • CRGD_HUMAN antibody
    • CRYG4 antibody
    • Crygd antibody
    • Crystallin, gamma D antibody
    • Crystallin, gamma-4 antibody
    • CTRCT4 antibody
    • Gamma crystallin D antibody
    • Gamma D crystallin antibody
    • Gamma-crystallin 4 antibody
    • Gamma-crystallin D antibody
    • Gamma-D-crystallin antibody
    • PCC antibody
    see all

Anti-CRYGD antibody images

  • All lanes : Anti-CRYGD antibody (ab69703) at 1/500 dilution

    Lane 1 : CRYGD transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 21 kDa
    Observed band size : 16 kDa (why is the actual band size different from the predicted?)

References for Anti-CRYGD antibody (ab69703)

ab69703 has not yet been referenced specifically in any publications.

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