Overview

  • Product nameAnti-CSEN antibody
    See all CSEN primary antibodies
  • Description
    Rabbit polyclonal to CSEN
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide surrounding amino acid 107 of human CSEN.

  • Positive control
    • Jurkat cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab41717 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 2 - 6 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 29 kDa).

    Can be blocked with CSEN peptide (ab55818).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCalcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
      Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
      May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
    • Tissue specificityHighly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
    • Sequence similaritiesBelongs to the recoverin family.
      Contains 4 EF-hand domains.
    • Post-translational
      modifications
      Palmitoylated. Palmitoylation enhances association with the plasma membrane.
      Proteolytically cleaved by caspase-3.
      Phosphorylation at Ser-63 inhibits cleavage by CASP3.
    • Cellular localizationCytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • 4933407H12Rik antibody
      • A type potassium channel modulatory protein 3 antibody
      • A-type potassium channel modulatory protein 3 antibody
      • AI413860 antibody
      • Calsenilin antibody
      • CSEN antibody
      • CSEN_HUMAN antibody
      • DRE antagonist modulator antibody
      • DRE-antagonist modulator antibody
      • DREAM antibody
      • EF hand transcription factor antibody
      • KCHIP 3 antibody
      • KChIP3 antibody
      • KCNIP 3 antibody
      • Kcnip3 antibody
      • Kv channel interacting protein 3 antibody
      • Kv channel-interacting protein 3 antibody
      • MGC18289 antibody
      • Potassium channel interacting protein 3 antibody
      • R74849 antibody
      see all

    References for Anti-CSEN antibody (ab41717)

    ab41717 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab41717.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"