• Product name
    Anti-CSEN (phospho S63) antibody
    See all CSEN primary antibodies
  • Description
    Rabbit polyclonal to CSEN (phospho S63)
  • Specificity
    ab62439 detects endogenous levels of CSEN only when phosphorylated at serine 63.
  • Tested applications
    Suitable for: ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic phosphopeptide derived from human CSEN around the phosphorylation site of serine 63 (D-S-SP-D-S).

  • Positive control
    • HeLa cells.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer
    Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab62439 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab62439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/500 - 1/1000.
ELISA 1/20000.


  • Function
    Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception.
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
    May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.
  • Tissue specificity
    Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
  • Sequence similarities
    Belongs to the recoverin family.
    Contains 4 EF-hand domains.
  • Post-translational
    Palmitoylated. Palmitoylation enhances association with the plasma membrane.
    Proteolytically cleaved by caspase-3.
    Phosphorylation at Ser-63 inhibits cleavage by CASP3.
  • Cellular localization
    Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 4933407H12Rik antibody
    • A type potassium channel modulatory protein 3 antibody
    • A-type potassium channel modulatory protein 3 antibody
    • AI413860 antibody
    • Calsenilin antibody
    • CSEN antibody
    • CSEN_HUMAN antibody
    • DRE antagonist modulator antibody
    • DRE-antagonist modulator antibody
    • DREAM antibody
    • EF hand transcription factor antibody
    • KCHIP 3 antibody
    • KChIP3 antibody
    • KCNIP 3 antibody
    • Kcnip3 antibody
    • Kv channel interacting protein 3 antibody
    • Kv channel-interacting protein 3 antibody
    • MGC18289 antibody
    • Potassium channel interacting protein 3 antibody
    • R74849 antibody
    see all

Anti-CSEN (phospho S63) antibody images

  • Immunofluorescence analysis of CSEN in HeLa cells, using ab62439 (1/500); in the presence or absence of phosphopeptide.

References for Anti-CSEN (phospho S63) antibody (ab62439)

ab62439 has not yet been referenced specifically in any publications.

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