• Product nameAnti-CSN1 antibody
    See all CSN1 primary antibodies
  • Description
    Rabbit polyclonal to CSN1
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) corresponding to a region within C terminal residues 400 - 471 of Human CSN1 (SwissProt entry Q13098).

  • Positive control
    • Prostate nodular hypertrophy.



Our Abpromise guarantee covers the use of ab84411 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesIHC-P: 1/100 - 1/500. Antigen retrieval with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionEssential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein-and mitogen-activated protein kinase-mediated signal transduction.
    • Tissue specificityWidely expressed.
    • Sequence similaritiesBelongs to the CSN1 family.
      Contains 1 PCI domain.
    • DomainThe PCI domain is necessary and sufficient for the interactions with other CSN subunits of the complex. Mediates the interaction with CAPN8.
      The N-terminal part (1-216), which is not required for deneddylating activity and CSN complex formation, is nevertheless essential for other aspects of CSN complex function, such as repression of c-fos/FOS expression.
    • Post-translational
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm. Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • COP9 signalosome complex subunit 1 antibody
      • COP9 signalosome subunit 1 antibody
      • COPS1 antibody
      • CSN 1 antibody
      • CSN1_HUMAN antibody
      • FUS6/COP11, Arabidopsis, homolog of antibody
      • G protein pathway suppressor 1 antibody
      • GPS-1 antibody
      • Gps1 antibody
      • JAB1-containing signalosome subunit 1 antibody
      • Protein GPS1 antibody
      • Protein MFH antibody
      • SGN1 antibody
      • Signalosome subunit 1 antibody
      see all

    Anti-CSN1 antibody images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human prostate nodular hypertrophy, using 1/250 ab84411 followed by DAB staining.

    References for Anti-CSN1 antibody (ab84411)

    ab84411 has not yet been referenced specifically in any publications.

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